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桥本甲状腺炎:双侧对称萎缩的甲状腺(大体)


可见对称的萎缩的甲状腺。该病人甲状腺功能低下,此为桥本甲状腺炎的终末病变。最初甲状腺肿大,并出现短暂的甲状腺功能亢进,随后甲状腺功能正常,数年后甲状腺萎缩,出现甲状腺功能减退。异常T细胞激活及随后的B细胞刺激导致自身抗体分泌引起桥本甲状腺炎。

桥本甲状腺炎:大体 低倍 高倍 免疫荧光一 免疫荧光二

This symmetrically small thyroid gland demonstrates atrophy. This patient was hypothyroid. This is the end result of Hashimoto's thyroiditis. Initially, the thyroid is enlarged and there may be transient hyperthyroidism, followed by a euthyroid state and then hypothyroidism with eventual atrophy years later. Hashimoto's thyroiditis results from abnormal T cell activation and subsequent B cell stimulation to secrete a variety of autoantibodies.


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