局灶性节段性肾小球硬化，肾小球中央有一片胶原硬化区。和微小病变性肾炎相比，局灶性节段性肾小球硬化的病人更容易发生非选择性蛋白尿、血尿、可发展为慢性肾衰、对皮质类固醇治疗不敏感。
This is focal segmental glomerulosclerosis (FSGS). An area of collagenous sclerosis runs across the middle of this glomerulus. In contrast to minimal change disease, patients with FSGS are more likely to have non-selective proteinuria, hematuria, progression to chronic renal failure, and poor response to corticosteroid therapy.
