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非毒性甲状腺肿:多结节性甲状腺肿(低倍镜)


多结节性甲状腺肿低倍镜图像。滤泡不规则增大,扁平上皮组织处于非增殖状态。弥漫性(非毒性)甲状腺肿早期就是这种病理变化,可能的病因如下,地方性甲状腺肿(在一些饮食缺碘地区可能发生)或少见的“非地方性”或散发性甲状腺肿 (年轻的成年女性多发)。甲状腺激素先天性合成异常引起的甲状腺肿极为少见。

甲状腺肿:胶样囊肿(大体) 弥漫性结节状 多结节性(显微镜)

The follicles are irregularly enlarged, with flattened epithelium, consistent with inactivity, in this microscopic appearance at low power of a multinodular goiter. The earlier phase of a diffuse (non-toxic) goiter leading up to this point may have resulted from either "endemic" goiter (seen in parts of the world where dietary deficiency of iodine may occur) or the uncommon "nonendemic" or sporadic goiter (young adult women are most often affected). Inborn errors of thyroid hormone biosynthesis leading to goiter are extremely uncommon.


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