肉芽肿性炎常发生于病因长期作用于机体，同时较强的免疫反应也贯穿始终。图示典型的肉芽肿呈圆形局限性的特点。中央巨细胞中可见两个小球体。
Granulomatous inflammation occurs in response to some agents which persist for a long time and require a more orchestrated immune response to fight them. The granuloma seen here demonstrates the typical rounded and focal nature of this type of inflammation. A couple of spherules of C. immitis are present in the giant cell in the center.