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斑点型(又称核颗粒型、核斑块型)

图示斑点型(又称核颗粒型、核斑块型),是针对可提取的核抗原,特别是核蛋白,的自身抗体的典型显现方式.此型并不是很特异,但可见于混合结缔组织病,包括SLE,硬皮病和多发性肌炎,但不伴有严重肾脏或肺脏疾病.甚至对于专家来说,自身免疫性疾病很难分类。


This is the so-called "speckled" pattern of staining which is more characteristic of the presence of autoantibodies to extractable nuclear antigens, particularly ribonucleoprotein. This pattern is not very specific, but may be seen with an entity called "mixed connective tissue disease" which is a mix between SLE, scleroderma, and polymyositis, but without serious renal or pulmonary disease. The autoimmune diseases are very hard to classify, even for the experts.

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