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原发性胆汁性肝硬化:小叶间胆管破坏


原发性胆汁性肝硬化是一种少见的自身免疫性疾病(多见中年妇女),表现为肝脏三联管(小叶间动脉、小叶间静脉、小叶间胆管)中的小叶间胆管破坏。患者血清中可检测到抗线粒体抗体。图中的门管区具有突出的慢性炎性浸润而胆小管丧失。随后可发生小结节性肝硬化。
This is a case of primary biliary cirrhosis, a rare autoimmune disease (mostly of middle-aged women) that is characterized by destruction of bile ductules within the triads of the liver. Antimitochondrial antibody can be detected in serum. Seen here in a portal tract is an intense chronic inflammatory infiltrate with loss of bile ductules. Micronodular cirrhosis ensues.

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