普鲁士蓝铁染色显示肝细胞和枯否细胞中含铁血黄素的蓝色颗粒。血色素沉着症或可以是原发的（病因大概为常染色体隐性遗传病），也可以是继发的（过多的铁摄取或吸收、肝脏疾病、大量输血）。血色素沉着症导致皮肤的青铜色色素沉着、糖尿病（累及胰腺）、心率失常（累及心肌）。
A Prussian blue iron stain demonstrates the blue granules of hemosiderin in hepatocytes and Kupffer cells. Hemochromatosis can be primary (the cause is probably an autosomal recessive genetic disease) or secondary (excess iron intake or absorption, liver disease, or numerous transfusions). Hemochromatosis leads to bronze pigmentation of skin, diabetes mellitus (from pancreatic involvement), and cardiac arrhythmias (from myocardial involvement).
