此恶性淋巴细胞体积大、有较丰富的细胞浆，核圆型或卵圆型，核仁明显，偶有核分裂像，诊断为弥漫大B细胞淋巴瘤(也称免疫母细胞淋巴瘤）。主要需要鉴别的是转移癌。免疫过氧化物酶技术检测，若存在单克隆免疫球蛋白将有助于确定恶性淋巴瘤。抗原CD19和CD20有助于确定为B细胞起源。
The malignant lymphocytes here are very large with a moderately abundant cytoplasm, and the nuclei are round to ovoid with prominent nucleoli and occasional mitoses. The diagnosis is diffuse large B cell lymphoma (also known as immunoblastic lymphoma). The major differential diagnosis in this case would be a metastatic carcinoma. The presence of monoclonal immunoglobulin as demonstrated by immunoperoxidase technique would help to confirm this lesion as a malignant lymphoma. Demonstration of CD19 and 20 antigens would classify it as B cell in origin.
