遗传性球形红细胞增多症中，窦状隙被RBC塞满，球形红细胞的渗透性脆性增加，因为RBC每单位体积的表面积减少。主要的临床症状是贫血，脾肿大和黄疸。短小病毒感染时可并发再障危象。
The sinusoids are packed with RBC's in this case of hereditary spherocytosis. The osmotic fragility of spherocytes is increased, because the RBC's have decreased surface area per unit volume. The major clinical features are anemia, splenomegaly, and jaundice. An aplastic crisis may occur with parvovirus infection.
