系统性硬化（硬皮病）病人食管蠕动障碍，因为黏膜下层纤维化。常常发生在食管，但也可以发生在上消化道任何地方。图示胃粘膜下层广泛纤维化，三色染色呈蓝色。
Esophageal motility problems can occur in patients with progressive systemic sclerosis (scleroderma) because the submucosa becomes fibrotic. This occurs most often in the esophagus, but may also be seen elsewhere in the GI tract. Here in the stomach, a trichrome stain demonstrates a blue submucosa because of the extensive fibrosis.
