胆总管结石症病人约占胆石症的10%。可见胆囊肿大，胆总管内见多个结石，胆囊腔和胆囊颈内也有结石。肝管或肝外胆管很少发生结石，然而在亚洲肝血吸血虫病时可形成色素性结石。胆总管结石症的并发症有胆管炎、胰腺炎，其次是胆汁性肝硬化和肝脓肿。
There is a large, dilated gallbladder to the right. The common bile duct has been opened to reveal the presence of multiple gallstones. There were also calculi within the gallbladder lumen and gallbladder neck. This is choledocholithiasis, a condition that occurs in about 10% of persons with cholelithiasis. It is rarely due to formation of calculi within intrahepatic or extrahepatic ducts, except in Asia where pigmented stones may form in association with infection by the liver fluke Opisthochis sinensis. Complications of choledocholithiasis include cholangitis, pancreatitis, secondary biliary cirrhosis, and hepatic abscess.