细胞器损伤所产生的多种变化，大多用电子显微镜才能看到。急性损伤往往导致整个细胞的损伤。一些损伤经多年累积形成。图示：在慢性酒精中毒损伤的肝细胞中的Mallory小体（红染球状物）由肝细胞骨架微丝组成，这种是一种介于肌球蛋白（粗）和肌动蛋白（细）之间的中间丝。
Cytoplasmic organelle damage leads to a variety of injury patterns, most of which are best seen by electron microscopy. Acute injuries tend to damage an entire cell, so specific organelle damage is beside the point. However, in some cases the damage can be cumulative over many years. Here are Mallory bodies (the red globular material) composed of cytoskeletal filaments in liver cells chronically damaged from alcoholism. These are a type of "intermediate" filament between the size of actin (thin) and myosin (thick).