血色素沉着症是由于铁过度的沉积而引起的。如图所示，经过普鲁士蓝铁染色后可见该病显微镜下的表现。铁的过度沉淀可导致心脏增大以及类似心肌病的心力衰竭，这使得血色素沉着症成为限制性心肌病的一种形式。
Hemochromatosis, with excessive iron deposition, can occur in the heart as shown here microscopically with Prussian blue iron stain. The excessive deposition of iron leads to heart enlargement and failure similar to a cardiomyopathy, making hemochromatosis a form of "restrictive" cardiomyopathy.