乳腺Paget病。值得注意的是皮肤过度角化，使其产生粗糙的红色鳞屑外形，且常有溃疡。浸润至真皮的大细胞说明位于下方的导管原位癌或浸润性导管癌向上皮内侵犯。 Paget's disease of the breast is shown here. Note the overlying hyperkeratosis of the skin, which helps to produce the rough, red, scaling appearance seen grossly, and there is often ulceration. The large cells infiltrating into the epidermis represent intraepithelial extension of an underlying ductal carcinoma in situ or invasive ductal carcinoma.