通过内皮损伤和/或释放促凝血物质进入血液循环使凝血系统被广泛激活是DIC产生的原因。严重感染、损伤、肿瘤形成和产科并发症以及其它疾病可以引起DIC。小纤维蛋白血栓可在脑、心脏、肺、肾以及其它器官的小动脉中形成，引起组织缺血。
弥散性血管内凝血(DIC)：肾小球毛细血管袢中纤维素性微血栓(高倍镜)
Disseminated intravascular coagulation (DIC) is a consequence of widespread activation of the coagulation system through endothelial injury and/or release of thromboplastic substances into the circulation. DIC can be seen with severe infections, trauma, neoplasia, and obstetric complications, among others. Small fibrin thrombi can form in small arteries of brain, heart, lungs, kidneys, and other organs to produce ischemic tissue damage.